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Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto Sunarto; Agnes Yuliasari; Sri Sutji Susilowati; Hendri Wasito; Triyadi Hendra Wijaya; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.

Antifungal activity of Calophyllum soulattri leaf extract on fungal isolate of coconut neera Eka Prasasti Rachmani; Rehana Rehana; Novia Ayu Rahmawati
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5929

Background: Coconut neera is susceptible to fungus contamination. Some plants, such as Calophyllum soulattri, can function as natural preservatives with antifungal properties. Objective: This study aimed to evaluate the antifungal activity of C. soulattri leaf extract as measured by minimum inhibitory concentration (MIC) and minimum killing concentration (MKC). Methods: A dilution method was used to isolate the fungus that contaminated coconut neera. MIC and MKC antifungal activity were then evaluated using the liquid dilution method. Results: The results indicated that the contaminant fungi found in coconut neera belonged to the genus Penicillium. The MIC was 12.5%, while the MKC was 18.75%. Conclusion: C. soulattri leaf extract has the potential to be developed as an antifungals for food preservation.

Emulgel formulation of wild cherry leaves (Antidesma bunius L. Spreng) extract and its antioxidant activity Windah Anugrah Subaidah; Yayuk Andayani; Dewa Ayu Puspaning Kumaradewi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.4036

Background: The ethanol extract of wild cherry leaves (Antidesma bunius L. Spreng) has been studied as a free anti-radical in an emulgel formulation. The purpose of this study is to determine the physical properties of an emulgel made from an ethanol extract of wild cherry leaves, as well as its anti-radical activity. Methods: The maceration method was used to extract wild cherry leaves in 96% ethanol, which were then evaporated with a rotary evaporator. An emulgel was prepared to contain a 3.56% thick extract. The physical properties of the emulgel were evaluated consisting of the organoleptic test, pH test, homogeneity test, spreadability test, and adhesion test. The DPPH was used to test free anti-radical activity. Results: The emulgel of the ethanol extract of wild cherry leaves had a yellowish-green, thick texture, a distinct aroma of the extract, was homogeneous, pH 6, spreadability ranged from 4.4-6.2 cm, and adhesion of 5.467 0.83 cm. Emulgel had a very weak antioxidant activity with an IC50 of 6238.41 ppm. Conclusion:

Antifungal activity of Calophyllum soulattri leaf extract on fungal isolate of coconut neera Eka Prasasti Rachmani; Hanif Nasiatul Baroroh; Rehana Rehana; Novia Ayu Rahmawati
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5929

Background: Coconut neera is susceptible to fungus contamination. Some plants, such as Calophyllum soulattri, can function as natural preservatives with antifungal properties. Objective: This study aimed to evaluate the antifungal activity of C. soulattri leaf extract as measured by minimum inhibitory concentration (MIC) and minimum killing concentration (MKC). Methods: A dilution method was used to isolate the fungus that contaminated coconut neera. MIC and MKC antifungal activity were then evaluated using the liquid dilution method. Results: The results indicated that the contaminant fungi found in coconut neera belonged to the genus Penicillium. The MIC was 12.5%, while the MKC was 18.75%. Conclusion: C. soulattri leaf extract has the potential to be developed as an antifungals for food preservation.

Pengaruh Tingkat Pengetahuan Terhadap Kepatuhan Pasien Minum Obat Anti Tuberkulosis (OAT) di Puskesmas Kota Pekalongan Purgiantari Purgiantari; Masita Wulandari Suryoputri; Nialiana Endah Endriastuti
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5661

Background: Adherence is one of the most critical factors in the success of pulmonary tuberculosis therapy. Non-compliance of patients taking anti-tuberculosis drug results in a high rate of treatment failure, increasing the risk of disease severity and death. Objective: This study aims to investigate the impact of knowledge level on patient compliance in taking anti-tubercular medication. Methods: This observational, cross-sectional study employed a total sampling method. The levels of knowledge and compliance were assessed using a validated questionnaire administered to patients with pulmonary tuberculosis at the Pekalongan City health center (Puskesmas). Results: Among the 52 participants, 44.23% (n=23) demonstrated a high level of knowledge, and 86.5% (n=45) exhibited good compliance. Spearman correlation test analysis revealed a significant influence of knowledge level on patient compliance in taking antituberculosis drugs (p=0.001, r=0.341), indicating that higher knowledge levels correspond to better patient compliance. Conclusion: The study suggests that patient compliance with antitubercular medication improves as knowledge level increases.

Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto Sunarto; Agnes Yuliasari; Sri Sutji Susilowati; Hendri Wasito; Triyadi Hendra Wijaya; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.

Emulgel formulation of wild cherry leaves (Antidesma bunius L. Spreng) extract and its antioxidant activity Windah Anugrah Subaidah; Yayuk Andayani; Dewa Ayu Puspaning Kumaradewi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.4036

Background: The ethanol extract of wild cherry (Antidesma bunius L. Spreng) leaves has been studied as a free anti-radical in an emulgel formulation. The purpose of this study is to determine the physical properties of an emulgel made from an ethanol extract of wild cherry leaves, as well as its anti-radical activity. Methods: The maceration method was used to extract wild cherry leaves in 96% ethanol, which were then evaporated with a rotary evaporator. An emulgel was prepared to contain a 3.56% thick extract. The physical properties of the emulgel were evaluated consisting of the organoleptic test, pH test, homogeneity test, spreadability test, and adhesion test. The DPPH was used to test free anti-radical activity. Results: The emulgel of the ethanol extract of wild cherry leaves had a yellowish-green, thick texture, a distinct aroma of the extract, was homogeneous, pH 6, spreadability ranged from 4.4-6.2 cm, and adhesion of 5.5 second. Emulgel had a very weak antioxidant activity with an IC50 of 6238 ppm. Conclusion: Further optimization of the formulation and storage conditions may be required to enhance the antioxidant potential of the wild cherry leaf extract emulgel for topical applications.

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

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Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kab. banyumas,

Jawa tengah

INDONESIA